The St.Thomas College of Arts and Science was established in 1999 as a co-educational institution which is governed by the St.Thomas Orthodox Syrian Cathedral Parish Trust of St.Thomas Orthodox Cathedral, Broadway. The Patron of our college is His Holiness Baselios Marthoma Mathews III, Catholicose of the East and Malankara Metropolitan. The founder Chairman was His Grace Dr. Yakoob Mar Irenios and the present Chairman is His Grace Gee Varghese Mar Philaxenos, Metropolitan of the Diocese of Madras of the Malankara Orthodox Syrian Church.

The college is governed by its board of trustees and administrated by its executive headed by His Grace Gee Varghese Mar Philaxenos-Chairman, Rev.Fr.Anish Mathew-Vice Chairman, Mr. Georgie Mathew K -Secretary, and Mr. Alex Abraham-Treasurer.

Dr. Rev. Francis Soundararaj (1999 - 2002) as its first Principal laid the successful foundation of this institution under his able leadership. The College was started under his guideship with 5 courses (B.Com., BCA, B.Sc. Computer Science, B.Sc. Visual Communication & BBA) affiliated wit the University of Madras. The second principal Dr. (Mrs.) S. Teresa Jane assumed office as principal in 2002. She was the principal of our college from 2002 - 2003. Dr. (Mrs.) Hemalatha Sundara Kumar was the third principal of our college from 2003. The college became a Post Graduate institution in 2003 with the introduction of M.Com., M.Sc. (Computer Science) & M.Sc. (Visual Communication). Many new courses such as B.Sc. Maths, B.Sc. Electronic Media & B.Sc. Psychology was introduced during her tenure. Prof. Mr. Avaram Abdul Hakeem, the fourth principal of our college held office for one year (2005 - 2006) . During the period two sections were introduced to B.Com., BCA and BBA courses. The fifth Principal Dr. S. Mathuram Selvaraja assumed charge as principal in 2006. He introduced many clubs such as the organization for Social Justice, Green Club, Women Upliftment Club, Consumer Club & Staff Club. He guided the institution for 3 years (2006 - 2009). Dr. C. Selvaraj was the sixth principal of our college from 2010 to 2013. Dr.J.Joel was our seventh principal from 2013-2015 .Dr. Samuel Sukumar , M.Sc., Ph.D. was the eighth principal from 2015 to 2018. Dr.N.Thangavel M.Com;M.B.A;PGDMM;PGDHRD;Ph.D;D.Lit; was the ninth principal from 2018 to 2023 .Our Present principal is Dr.T.S.Prema assumed charge on 21.07.2023.